Multisite neuroimaging trials

On Wilcoxon Comparisons for Multisite Glinical Trials

SUMMARY New rank-based methods for analyzing data from multisite clinical trials are presented ·in the context of "mixed" linear models. In contrast to current rank methods, the new procedures test for a drug main effect in the presence of a random drug by site interaction (or drug by investigator interaction when there is only one investigator per site). Analogous procedures are also provided ...

Multisite international collaborative clinical trials in mania.

Gustavo Vázquez, Ross J. Baldessarini, Ayşegül Yildiz, Jorge Tamayo, Leonardo Tondo and Paola Salvatore 1 Department of Neuroscience, Palermo University, Buenos Aires, Argentina 2 International Consortium for Bipolar Disorder Research, McLean Hospital, Belmont, MA, USA 3 Department of Psychiatry, Harvard Medical School, Boston, MA, USA 4 Department of Psychiatry, Dokuz Eylül University, Izmir, ...

Neuroimaging Outcomes of Brain Training Trials

Pitfalls of multisite randomized clinical trials of efficacy and effectiveness.

This article discusses common pitfalls of multisite randomized clinical trials of efficacy and effectiveness. Issues considered include (1) premature initiation, (2) ineffective study structure, (3) too much or too little communication among researchers, (4) neglect of site differences, (5) use of "naked" p values, (6) premature closure, and (7) overreliance on the interpretation and memory of ...

Multisite clinical trials in strict accordance with GMP standards?

Thomas Poe looks at what the future holds for global research using today's technology and provides a clear roadmap showing how to get there efficiently.